So, the fact that my main e-mail client (Mailpile) and my social media (Mastodon) are both browser-based means that I cannot easily open random links coming my way through these channels in a separate cube, using porcupine: https://micahflee.com/2016/06/qubes-tip-opening-links-in-your-preferred-appvm/
This is less than ideal. Why does everything have to be browser-based these days.
@Ca_Gi Electron, Electron, and a webview-based thing. I only have 16GiB of RAM, can't afford to run that many Electron apps.