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"ACAM2000 is administered as a Vaccinia virus preparation that is inoculated into the skin by pricking the skin surface. Following a successful inoculation, a will develop at the site of the vaccination (i.e., a “take”). The growing at the site of this inoculation lesion can be spread to other parts of the body or even to other people. Individuals who receive vaccination with ACAM2000 must take precautions to prevent the spread of the vaccine virus and are considered vaccinated within 28 days."

cdc.gov/poxvirus/monkeypox/cli

www.cdc.govMonkeypox and Smallpox Vaccine Guidance | Monkeypox | Poxvirus | CDCSmallpox Vaccine Guidance. Monkeypox is a viral disease that occurs mostly in central and western Africa. It is called monkeypox because it was first identified in laboratory monkeys. However, it is much more common among animals such as rats, mice, rabbits, and the African Squirrel.